联系方式

电话/传真：025-89680356
电子邮件：hlliu@nju.edu.cn
办公室：南京大学环境学院大楼B522
通讯地址：南京市栖霞区仙林大道163号，210023
课题组网址：http://www.ydzlx.com/zhangxw/
欢迎热爱环境分析、环境生态风险和人体健康风险评价的同学报考研究生。同时欢迎博士后研究人员, 访问学者研究人员以及科研助理人员加盟。
        1991年考入江苏省盐城中学，1998和2007年分别在河海大学和南京大学获得学士和博士学位， 2007年并留南京大学任教，2013年赴加拿大萨省大学从事访问研究，现主要从事有机污染物对斑马鱼早期发育动态影响过程，内分泌干扰效应及作用机制研究，同时开展本土生物不同营养级水平的毒理学效应研究，应用于化学品（农药）生态危害评估、风险预警和水质基准、标准建设。发表文章60余篇，其中SCI论文近50篇，包括在国际权威学术刊物Environmental Science & Technology上发表论文7篇，其h index 为14，5项发明专利，主持了3项国家自然科学基金面上项目并参与了自然基金重点项目，973项目和水专项多项。

教育背景：

2002.09~2007.06      南京大学 环境学院 获博士学位 (导师：于红霞教授)
1994.09~1998.06      河海大学 水文水资源与环境学院 获学士学位

工作经历：

2011.12~     今        南京大学 环境学院 副教授
2013.07~2014.07      加拿大University of Saskatchewan 访问学者
2007.07~2011.12      南京大学 环境学院 讲师
1998.07~2002.08      江苏省阜宁县环保局 工程师

研究领域：

环境污染物生态毒理、化学品危害评估，水环境质量基准标准研究

主持项目：

2018.01-2021.12，国家水体污染控制与治理科技重大专项：典型优控污染物保护水生生物水质标准推荐值在太湖水生态功能区的应用No. 2018ZX07208001
2017.01-2020.12，国家自然科学基金面上项目：基于斑马鱼/幼鱼研究新型溴代阻燃剂的发育影响及受体调控内分泌干扰交互作用机制
2014.01-2017.12，国家自然科学基金面上项目：基于斑马鱼胚胎研究阻燃剂的生物有效性和内分泌干扰分子机制
2010.01-2012.12，国家自然科学基金面上项目：淡水鱼体内多溴联苯醚的代谢过程解析及其代谢物污染现状与危害性研究
2011.12-2013.12，国家环保部：农药安全评估
2011.09-2013.06，江苏省环保厅：基于生物的工业废水排放毒性削减评价体系研究
2009.01-2011.12，教育部：水体复合污染有机毒物化学监控和内分泌干扰毒性甄别。
2008.12-2010.06，江苏省环保厅：几种典型废水应急生物监测方法研发
2007.08-2008.04，江苏省环境监测分包项目：江苏省集中式饮用水源地有毒有害有机污染物毒性筛选
2007.09-2009.12，南京大学人才引进启动项目：多溴联苯醚及其代谢物内分泌干扰毒性研究

参加项目：

2017.07-2020.12, 国家水体污染控制与治理科技重大专项：课题，流域水环境基准及标准制定方法技术集成，子课题，流域水环境质量基准向标准转化技术集成，No. 2017ZX07301-002
2012.01-2015.12，国家水体污染控制与治理科技重大专项：水专项监控预警主题，流域水生态承载力调控与污染减排管理技术研究项目，重点流域优控污染物水环境质量基准研究课题，典型流域优控污染物水生生物基准研究与校验No. 2012ZX07501-003-02
2012.01-2015.12，国家水体污染控制与治理科技重大专项：水专项监控预警主题，流域水生态承载力调控与污染减排管理技术研究项目，水生态功能分区与标准管理工程建设课题子课题2：基于水生态功能分区的水质标准管理与示范No. 2012ZX07506-001
2008.07-2012.12，国家重点基础研究发展计划（973计划）：湖泊蓝藻水华生态灾害形成机理及防治的基础研究，蓝藻水华衍生污染物的毒理效应与健康风险No. 2008CB418102
2008.08-2010.12，国家水体污染控制与治理科技重大专项：国家水专项监控预警主题，流域水生态功能分区与水质目标管理技术项目，流域水环境质量基准与标准技术No. 2008ZX08526-003
2008.01-2011.12，国家自然科学基金重点项目：持久性有机污染物的典型环境过程及构效关系研究No. 20737001
2009.01-2010.06，江苏省省级环保科技项目：多相光催化联用技术研发No. 2008005
2008.01-2009.12，江苏省省级环保科技项目：环保科技信息系统的建设及其维护更新技术研究No. 2007013

主要研究成果：

一作或通讯作者发表

32）Zhang L, Xu EGB, Li YB, Liu HL*, Vidal-Dorsch DE, Giesy JP. Ecological risks posed by ammonia nitrogen (AN) and un-ionized ammonia (NH3) in seven major river systems of China, Chemosphere, 2018, 202, 136-44.
31) Liu HL, Ma ZY, Zhang T, Yu NY, Su GY, Giesy JP, Yu HX*. Pharmacokinetics and effects of tetrabromobisphenol a (TBBPA) to early life stages of zebrafish (Danio rerio). Chemosphere, 2018, 190, 243-52.
30) Zhang L, Jin YR, Liu HL*, Shi LH, Doering JA, Tang S, Giesy JP. Yu HX. Integrated in Silico and in Vivo Approaches to Investigate Effects of BDE-99 Mediated by the Nuclear Receptors on Developing Zebrafish. Environ Toxic Chem, 2017, 9999, 1-8.
29) Li YB, Xu EGB, Liu W, Chen Y, Liu HL*, Li D, Liu ZT, Giesy JP, Yu HX. Spatial and temporal ecological risk assessment of unionized ammonia nitrogen in Tai Lake, China (2004-2015), Ecotox Environ Saf, 2017, 140, 249-55.
28) Wu Y, Su GY, Tang S, Liu W, Ma ZY, Zheng XM, Liu HL*, Yu HX*. The combination of in silico and in vivo approaches for the investigation of disrupting effects of tris (2-chloroethyl) phosphate (TCEP) toward core receptors of zebrafish. Chemosphere, 2017, 168: 122-130.
27) Wu Y, Doering JA, Ma ZY, Tang S, Liu HL*, Zhang XW, Wang XX, Yu HX*. Identification of androgen receptor antagonists: in vitro investigation and classification methodology for flavonoid. Chemosphere, 2016, 158:72-79.
26) Ma ZY, Tang S, Su GY, Miao YQ, Liu HL*, Xie YW, Giesy J., Saunders D.M.V., Hecker M, Yu HX. Effects of tris (2-butoxyethyl) phosphate (TBOEP) on endocrine axes during development of early life stages of zebrafish (Danio rerio). Chemosphere, 2016,144:1920-1927 
25) Chen Y, Yu SY, Tang S, Li YB, Liu HL*, Zhang XH, Su GY, Li B, Yu HX, Giesy J. Site-specific water quality criteria for aquatic ecosystems: A case study of pentachlorophenol for Tai Lake, China. Sci Total Environ, 2016, 541: 65-73. 
24) Ma ZY, Yu YJ, Tang S, Liu HL*, Su GY, Xie YW, Giesy J, Hecker M, Yu HX. Differential modulation of expression of nuclear receptor mediated genes by tris (2-butoxyethyl) phosphate (TBOEP) on early life stages of zebrafish (Danio rerio). Aquatic Toxicol, 2015, 169:196-203. 
23) Liu HL*, Tang S, Zheng XM, Zhu YT, Ma ZY, Liu CS, Hecker M, Saunders D, Giesy J, Zhang XW, Yu HX*. Bioaccumulation, biotransformation and toxicity of BDE-47, 6-OH-BDE-47 and 6-MeO-BDE-47 in early life-stages of zebrafish (Danio rerio). Environ Sci Technol, 2015, 49 (3): 1823-33.
22) Li YB, Han ZH, Zheng XM, Ma ZY, Liu HL*, Giesy JP, Xie YW, Yu HX. Comparison of waterborne and in ovo nanoinjection exposures to assess effects of PFOS on Zebrafish embryos. Environ Sci Pollut Res, 2015, 22: 2303-10.
21) Wen Q, Liu HL*, Zhu YT, Zheng XM, Su GY, Zhang XW, Yu HX*, Giesy JP, Lam MHW. Maternal transfer, distribution, and metabolism of BDE-47 and its related hydroxylated, methoxylated analogs in zebrafish (Danio rerio). Chemosphere, 2014, 120C: 31-6.
20) Shi R, Yang CH, Su RH, Jin JR, Chen Y, Liu HL*, Giesy JP, Yu HX. Weighted Species Sensitivity Distributions Method to Derive Site-Specific Quality Criteria for Copper in Tai Lake, China. Environ Sci Pollut Res, 2014, 21:12968-78.
19) Chen Y, Huang J, Xing LQ, Liu HL*, Giesy J P, Yu HX, Zhang XW. Effects of Multi-generational exposures of D. magna to Environmentally Relevant Concentrations of Pentachlorophenol. Environ Sci Pollut Res, 2014, 21: 234-43.
18) Xing LQ, Liu HL*, Zhang XW, Hecker M, Giesy JP, Yu HX. A comparison of statistical methods for deriving freshwater quality criteria for the protection of aquatic organisms. Environ Sci Pollut Res, 2014, 21: 159-67.
17) Zheng XM, Zhu YT, Liu CS, Liu HL*, Giesy JP, Hecker M, Lam MHW, Yu HX*. Accumulation and biotransformation of BDE-47 by zebrafish larvae and teratogenicity and expression of genes along the hypothalamus –pituitary -thyroid axis. Environ Sci Technol, 2012, 46(23): 12943-51.
16) Xing LQ, Liu HL*, Giesy JP, Yu HX*. pH-dependent aquatic criteria for 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol. Sci Total Environ, 2012, 441C：125-31.
15) Xing LQ, Sun J, Liu HL*, Yu HX*. Combined toxicity of three chlorophenol 2,4-dichlorophenol, 2,4,6-trichlorophenol, and pentachlorophenol to Daphnia magna. J Environ Monit, 2012, 14(6), 1677-1683. 氯酚对大型蚤的混合毒性[J]. 环境化学, 2012, 31(10): 1667. (invited,通讯)
14) Zheng XM, Liu HL*, Shi W, Wei S, Giesy JP, Yu HX*. Effects of Perfluorinated Compounds on Development of Zebrafish Embryos. Environ Sci Pollut Res, 2012, 19：2498-505.
13) Wen Q, Liu HL, Su GY, Wei S, Feng JF, Yu HX*. Determination of Polybrominated Diphenyl Ethers and Their Derivates in Zebrafish Eggs. Chine J Anal Chem 2012, 40 (11): 1698-702. 温泉,刘红玲,苏冠勇,韦斯,冯建昉,于红霞*. 斑马鱼卵中多溴联苯醚及其衍生物的同步分析, 分析化学, 2012,40(11): 1698-702 (translated).
12) Xing LQ, Liu HL, Giesy JP, Zhang XW, Yu HX*. Probabilistic ecological risk assessment for three chlorophenols in surface water of China. J Environ Sci, 2012, 24(2): 329-34.
11) Shi W, Zhang FX, Hu GJ, Hao YQ, Zhang XW, Liu HL*, Wei S, Wang XR, Giesy JP, Yu HX*. Thyroid hormone disrupting activities associated with phthalate esters in water sources from Yangtze River Delta. Environ Int, 2012, 42：117-23.
10) Liu HL, Hu W, Sun H, Shen OX, Wang XR, Lam MHW, Giesy JP, Zhang XW, Yu HX*. In vitro profiling of endocrine disrupting potency of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) and related hydroxylated analogues (HO-PBDEs). Mar Pollut Bull, 2011, 63: 287-96.
9) Hu W, Liu HL*, Sun H, Shen OX, Wang XR, Lam MHW, Giesy JP, Zhang XW, Yu HX*. Endocrine effects of methoxylated brominated diphenyl ethers in three in vitro models. Mar Pollut Bull, 2011, 62：2356-61.
8) Shi W, Zhang FX, Zhang XW, Su GY, Wei S, Liu HL*, Cheng SP, Yu HX*. Identification of trace organic pollutants in freshwater sources in Eastern China and estimation of their associated human health risks. Ecotoxicology, 2011, 20(5): 1099-106.
7) Shi W, Wang XY, Hu GJ, Hao YQ, Zhang XW, Liu HL*, Wei S, Wang XR, Yu HX*. Bioanalytical and instrumental analysis of thyroid hormone disrupting compounds in water sources along the Yangtze River. Environ Pollut, 2011, 159: 441-8.
6) Zhang FX, Hu W, Yu HX, Sun H, Shen OX, Wang XR, Liu HL^*, Lam M H W, Giesy JP, Zhang XW. Endocrine disruption effects of 2, 2', 4, 4', 6 -pentabromodiphenylether (BDE100) in reporter gene assay. J Environ Monit, 2011, 13 (4): 850-4.
5) Liu HL, Chen JT, Wan, FY, Wang ZY, Wang LS. Theoretical Study on the Thermodynamic Properties and Stability of Polybrominated Diphenyl Sulfide Catena. Acta Chimica Sinica, 2010, 68(6): 540-50.
4) Liu HL, Yu HX*, Giesy JP, Xu TL, Zhou Y. Response of antioxidant parameters to 3,3’-dimethyl-benzidine in goldfish (Carassius auratus) liver. Fresen Environ Bull, 2009, 18 (5a): 737-43.
3) Liu HL, Chen JN, Jiang J, Giesy JP, Yu HX*, Wang XR. Cytotoxicity of HC Orange NO.1 to L929 fibroblast cells. Environ Toxic Pharm, 2008, 26 (3): 309-14.
2) Liu HL, Yu Y, Kong FX, He LN, Yu HX*, Giesy JP, Wang XR. Effects of tetrabromobisphenol A on the green alga Chlorella pyrenoidosa. J Environ Sci Heal A, 2008, 43 (11): 1271-8.
1) Liu HL, Yu HX*, Giesy JP, Sun YY, Wang XR. Toxicity of HC Orange No.1 to Daphnia magna, Zebrafish (Brachydanio rerio) embryos and goldfish (Carassius auratus). Chemosphere, 2007, 66 (11): 2159-65.

合作发表

26) Su GY, Saunders D, Yu YJ, Yu HX, Zhang XW, Liu HL, Giesy JP. Occurrence of additive brominated flame retardants in aquatic organisms from Tai Lake and Yangtze River in Eastern China, 2009-2012. Chemosphere, 2014, 114: 340-6.
25) Han ZH, Wang QW, Fu J, Chen HS, Zhao Y, Zhou BS, Gong ZY, Wei S, Li J, Liu HL, Zhang XW, Liu CS*, Yu HX. Multiple bio-analytical methods to reveal possible molecular mechanisms of developmental toxicity in zebrafish embryos/larvae exposed to tris(2-butoxyethyl) phosphate. Aquat Toxicol, 2014, 150: 175-81.
24) Li XL, Wang XX, Shi W, Liu HL, Yu HX*. Analysis of Ah receptor binding affinities of polybrominated diphenyl ethers via in silico molecular docking and 3D-QSAR. SAR QSAR in Environ Res, 2013, 24(1): 75-87.
23) Li XL, Ye L, Shi W, Liu HL, Liu CS, Qian XP, Zhu YL, Yu HX*.  In silico study on hydroxylated polychlorinated biphenyls as androgen receptor antagonists. Ecotoxicol Environ Saf, 2013, 92: 258-64.
22) Li X, Ye L, Wang X, Shi W, Liu H, Qian X, Zhu Y, Yu H. In silico investigations of anti-androgen activity of polychlorinated biphenyls. Chemosphere, 2013, 2(7): 795-802.
21) Fu J, Han J, Zhou B, Gong Z, Santos EM, Huo X, Zheng W, Liu H, Yu H, Liu C. Toxicogenomic responses of zebrafish embryos/larvae to tris(1,3-dichloro-2-propyl) phosphate (TDCPP) reveal possible molecular mechanisms of developmental toxicity. Environ Sci Technol, 2013, 47(18): 10574-82.
20) Su GY, Liu XH, Gao ZS, Xian QM, Feng JF, Zhang XW, Wei S, Liu HL, Yu HX*. Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) in fish & meat in diets of residents of Nanjing, China. Environ Int, 2012, 42: 138-43.
19) Su GY, Zhang XW*, Liu HL, Giesy JP, Lam M, Lam P, Siddiqui M, Musarrat J, Al-Khedhairy A, Yu HX*. Toxicogenomic Mechanisms of 6-HO-BDE-47, 6-MeO-BDE-47 and BDE-47 in E. Coli. Environ Sci Technol, 2012, 46(2): 1185-91.
18) Su G, Xia J, Liu H, Lam MH, Yu H, Giesy JP, Zhang X. Dioxin-like potency of HO- and MeO- analogues of PBDEs' the potential risk through consumption of fish from eastern China. Environ Sci Technol. 2012, 46(19): 10781-8.
17) Shi W, Hu X, Zhang F, Hu G, Hao Y, Zhang X, Liu H, Wei S, Wang X, Giesy JP, Yu H. Occurrence of thyroid hormone activities in drinking water from eastern China: contributions of phthalate esters. Environ Sci Technol. 2012 46(3):1811-8.
16) Liu CS, Wang QW, Liang K, Liu JF, Zhou SB, Zhang XW, Liu HL, Giesy JP, Yu HX. Effects of tris (1, 3-dichloro-2-propyl) phosphate and triphenyl phosphate on receptor-associated mRNA expression in zebrafish embryos/larvae. Aquat Toxicol, 2012, 128-129, 147-57.
15) Liu C, Yan W, Zhou B, Guo Y, Liu H, Yu H, Giesy JP, Wang J, Li G, Zhang X. Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos. Aquat Toxicol. 2012, 118-119:108-15.
14) Li XL, Ye L, Wang XX, Wang XZ, Liu HL, Zhu YL, Yu HX*. Combined 3D-QSAR, molecular docking and molecular dynamics study on thyroid hormone activity of hydroxylated polybrominated diphenyl ethers to thyroid receptors β. Toxicol Appl Pharmacol, 2012, 265: 300-7.
13) Li XL, Ye L, Wang XX, Wang XZ, Liu HL, Qian XP, Zhu YL, Yu HX*. Molecular docking, molecular dynamics simulation, and structure-based 3D-QSAR studies on estrogenic activity of hydroxylated polychlorinated biphenyls. Sci Total Environ, 2012, 441: 230-8.
12) Li XL, Wang ZY, Liu HL, Yu HX*. Quantitative structure–activity relationship for prediction of the toxicity of phenols on Photobacterium phosphoreum. Bull Environ Contam Toxicol, 2012, 89: 27-31.
11) Yang WH, Wei S, Liu HL, Yu HX*. Insights into the structural and conformational requirements of polybrominated diphenyl ethers and metabolites as potential estrogens based on molecular docking. Chemosphere, 2011, 84(3): 328-35.
10) Zhang X, Wiseman S, Yu H, Liu H, Giesy JP, Hecker M. Assessing the toxicity of naphthenic acids using a microbial genome wide live cell reporter array system. Environ Sci Technol. 2011 45(5): 1984-91.
9) Yang WH, Wang ZY, Liu HL, Yu HX*. Exploring the binding features of polybrominated diphenyl ethers as estrogen receptor antagonists: docking studies. SAR QSAR Environ Res, 2010, 21(3): 351-67.
8) Yang WH, Liu XH, Liu HL, Wu Y, Giesy JP, Yu HX*. Molecular Docking and Comparative Molecular Similarity Indices Analysis Study of Estrogenicity of Polybrominated Diphenyl Ethers and Their Analogues. Environ Toxicol Chem, 2010, (29): 660-8.
7) Wang XY, Shi W, Wu J, Hu GJ, Hao YQ, Liu HL, Han XD, Yu HX*. The reproductive toxicity of organic extracts from petrochemical plant effluents discharged to Yangtze River, China. J Environ Sci, 2010, 22(2): 297-303.
6) Li XD, Xing QM, Liu HL, Hua RM, Xu SS, Chen HY, Yu HX*. Simultaneous Determination of Three Sulfonamides Residues in Vegetable by High Performance Liquid Chromatographic Method with Fluorimetric Detection. Chine J Anal Chem, 2010, 38(3): 429-33.
5) Yu YJ, Liu HL, Dai XL, Cai HX, Li CY, Yu HX*. Trace analysis of phenols and chlorophenols in water by in-situ derivatization headspace solid-phase microextraction coupled with GC/MS. Chine J Anal Chem, 2010, 38 (9): 1243-8.
4) 苏冠勇，温  泉，韦  斯，冯建昉，刘红玲，于红霞*, 细胞培养液中多溴联苯醚以及代谢产物的GC-MS/MS测定方法. 分析化学，2010, 361-6.
3) Shi W, Wang XY, Hu W, Sun H, Shen QX, Liu HL, Wang XR, Giesy JP, Cheng SP, Yu HX*. Endocrine-disrupting equivalents in industrial effluents discharged into Yangtze River Compounds. Ecotoxicology, 2009, 18: 685-92
2) Chen JT, Liu HL, Wang FY, Yu HX, Li DL. QSPR Study on the Boiling Points of Some Oxygen and Sulfur-containing Organic Compounds. Chine J Struct Chem, 2009, 18(12): 1561-8.
1) Sun YY, Yu HX*, Zhang JF, Yin Y, Shen H, Liu HL, Wang XR. Bioaccumulation and antioxidant responses in goldfish Carassius auratus under HC Orange No. 1 exposure. Ecotoxicol Environ Saf, 2006, 63: 430-7.
（https://www.researchgate.net/profile/Hongling_Liu）

参与书籍

1、《环境化学实验》再版，科学出版社，2011
2、《环境监测实验》再版，科学出版社，2012

专利

刘红玲，郑新梅，陈怡，于红霞.  一种用于有机污染物毒性测试的显微注射系统及显微注射方法和应用. 专利申请号：201210589394.X 专利公开号：CN102994371A 专利授权号：2014102300093290
刘红玲，郑新梅，沈燕飞，于红霞，冯政.一种废水在线监测方法和装置. 专利申请号：201110069399.5. 专利公开号：CN102207485A.
刘红玲，李亚兵, 陈怡，于红霞.一种造纸废水的毒性鉴别评价方法. 专利申请号: 201410339751.6
王英，储升，刘红玲，吴国豪，郑新梅，冯政，韩磊磊，孔飞，于红霞，邹志明.一种光催化-氧化深度净化有机毒物分水的方法及所用光催化材料的制备方法.专利申请号: 201010107757.2. 专利公开号：CN101838078A
于红霞，苏冠勇，邬旸，温泉，韦斯，刘红玲，一种固相萃取耦合固相微萃取的分析方法， ZL 200910264231.2

国际交流合作

团队有广泛的国际合作交流，分别与美国、加拿大、香港等国家和地区的顶级环境科学研究机构开展实质性的科研合作与人员交流，取得丰硕成果。